Studies on Synthesis and Anthelmintic Activities of Some N-Benzylidenepyridin-2-amines

A series of N-benzylidenepyridin-2-amines (1a-j) were synthesized by heating 2-aminopyridine with different substituted aromatic aldehydes in the presence of toluene. The structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR, 13C NMR and mass spectral data. The compounds 1a-j were screened for anthelmintic activity. Test results revealed that the compounds showed paralysis time of 0.27 to 1.52 min and death time of 0.42 to 4.42 min, whereas the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 min and death time of 2.16 and 2.47 min, respectively at the same concentration of 1% (m/V). Five compounds, N(2-hydroxybenzylidene) pyridin-2-amine (1e), N(4-bromobenzylidene) pyridin2-amine (1g), N(4-nitrobenzylidene) pyridin-2-amine (1h), N(4-hydroxybenzylidene) pyridin-2-amine (1i) and N(4-methoxybenzylidene) pyridin-2-amine (1j) showed the highest anthelmintic activity.